Genital Herpes Vaccine

"Findings Recommend Herpes Vaccine for Human Trials," Focus, January 14, 2005.

"Herpes Vaccine Developed at HMS Licensed for Preclinical Trials", Focus, March 7, 2008.

"Acambis initiates pre-clinical testing with herpes vaccine from Harvard Medical School", Press Release, February 25, 2008

Publications on the Vaccine

Da Costa, X.J., C.A. Jones and D.M. Knipe. 1999. Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection. Proceedings of the National Academy of Sciences, USA 96:6994-6998. (pdf)

Da Costa, X.J., M.F. Kramer, J. Zhu, M.A. Brockman and D.M. Knipe. 2000. Construction, phenotypic analysis and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2. Journal of Virology 74:7963-7971. (pdf)

Hoshino, Y., S.K. Dalai, K. Wang, L. Pesnicak, T.Y. Lau, D.M. Knipe, J.I. Cohen, and S.E. Straus. 2005. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs. Journal of Virology 79:410-418. (pdf)