Department of Microbiology
Blavatnik Institute
Harvard Medical School
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Publications

  1. Goldman, R.D. and D.M. Knipe. 1973. Functions of cytoplasmic fibers in non-muscle cell motility. Cold Spring Harbor Symposium on Quantitative Biology 37:523-534.
  2. Rose, J. and D.M. Knipe. 1975. Nucleotide sequence complexities, molecular weights, and poly (A) content of the vesicular stomatitis virus mRNA species. Journal of Virology 15:994-1003.
  3. Knipe, D.M., J. Rose, and H. Lodish. 1975. Translation of individual species of vesicular stomatitis viral mRNA. Journal of Virology 15:1004-1011.
  4. Knipe, D.M., H.F. Lodish, and D. Baltimore. 1977. Localization of two cellular forms of the vesicular stomatitis viral glycoprotein. Journal of Virology 21:1121-1127.
  5. Knipe, D.M., D. Baltimore, and H.F. Lodish. 1977. Separate pathways of maturation of the major structural proteins of vesicular stomatitis virus. Journal of Virology 21:1128-1139.
  6. Knipe, D.M., H.F. Lodish, and D. Baltimore. 1977. Analysis of the defects of temperature-sensitive mutants of vesicular stomatitis virus: Intracellular degradation of specific viral proteins. Journal of Virology 21:1140-1148.
  7. Knipe, D.M., D. Baltimore, and H.F. Lodish. 1977. Maturation of viral proteins in cells infected with temperature-sensitive mutants of vesicular stomatitis virus. Journal of Virology 21:1149-1158.
  8. Katz, F., J.E. Rothman, D.M. Knipe and H.F. Lodish. 1977. Membrane assembly: Synthesis and intracellular processing of the vesicular stomatitis viral glycoprotein. Journal of Supramolecular Structure 7:353-370. (PubMed)
  9. Katz, F., J.E. Rothman, D.M. Knipe, and H.F. Lodish. 1977. Membrane assembly: Synthesis and intracellular processing of the vesicular stomatitis viral glycoprotein. In: Cell Surface Carbohydrates and Biological Recognition. Progress in Clinical and Biological Research. Vol. 23. ICN-UCLA Symposia on Molecular Biology, V.T. Marchesi, V. Ginsberg, P. Robbins, E.F. Fox, eds. Liss, Inc., New York.
  10. Lodish, H.F., F. Katz, J.E. Rothman, and D.M. Knipe. 1977. Membrane assembly: Synthesis and intracellular processing of the vesicular stomatitis viral glycoprotein. In: Molecular Basis of Cell-Cell Interaction. Birth Defects: March of Dimes Original Article Series, Vol. XIV, No. 2, pp. 155-175. R.A. Lerner and D. Bergsma, eds. Liss, Inc., New York.
  11. Knipe, D.M., W.T. Ruyechan, B. Roizman, and I.W. Halliburton. 1978. Molecular genetics of herpes simplex virus: Demonstration of regions of obligatory and non-obligatory identity within diploid regions of the genome by sequence replacement and insertion. Proc. Natl. Acad. Sci. U.S.A. 75:3896-3900.
  12. Roizman, B., R.J. Jacob, D.M. Knipe, L.S. Morse, and W.T. Ruyechan. 1978. On the structure, functional equivalence and replication of the four arrangements of herpes simplex virus DNA. Cold Spring Harbor Symposium on Quantitative Biology 43:809-826. (PubMed)
  13. Ruyechan, W.T., L.S. Morse, D.M. Knipe, and B. Roizman. 1979. Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells. Journal of Virology 29:677-697.
  14. Knipe, D.M., W.T. Ruyechan, and B. Roizman. 1979. Molecular genetics of herpes simplex virus. III. Fine mapping of a genetic locus determining resistance to phosphonoacetate by two methods of marker transfer. Journal of Virology 29:698-704.
  15. Knipe, D.M., W.T. Ruyechan, R.W. Honess, and B. Roizman. 1979. Molecular genetics of herpes simplex virus. IV. The terminal a sequences of the L and S components are obligatorily identical and consitute a part of a structural gene mapping predominantly in the S component. Proc. Nat. Acad. Sci. USA 76:4534-4538.
  16. Knipe, D.M., W. Batterson, and B. Roizman. 1980. A gene function of herpes simplex virus required for expression of all early viral genes. "Animal Virus Genetics," ICN-UCLA Symposia on Molecular and Cellular Biology, Vol. XVIII, B. Fields, R. Jaenisch and C.F. Fox, eds. Academic Press, New York, N.Y. pp. 369-378.
  17. Roizman, B., W. Batterson, and D.M. Knipe. 1980. The potential significance of late herpes simplex virus functions expressed early in replication: The tale of a temperature-sensitive mutant. Perspectives in Virology 11:77-92.
  18. Knipe, D.M., W. Batterson, C. Nosal, B. Roizman, and A. Buchan. 1981. Molecular genetics of herpes simplex virus. VI. Characterization of a temperature-sensitive mutant defective in the expression of all early viral gene products. Journal of Virology 38:539-547.
  19. Conley, A.J., D.M. Knipe, P.C. Jones, and B. Roizman. 1981. Molecular genetics of herpes simplex virus. VII. Characterization of a temperature-sensitive mutant produced by in vitro mutagenesis and defective in DNA synthesis and accumulation of gamma polypeptides. Journal of Virology 37:191-206.
  20. Knipe, D.M. 1982. Cell growth transformation by herpes simplex virus. Progress in Medical Virology 28:114-144. (PubMed)
  21. Knipe, D.M., and A.E. Spang. 1982. Definition of a series of stages in the association of two herpesviral proteins with the cell nucleus. Journal of Virology 43:314-324.
  22. Knipe, D.M., M.P. Quinlan, and A.E. Spang. 1982. Characterization of two conformational forms of the major DNA-binding protein encoded by herpes simplex virus 1. Journal of Virology 44:736-741.
  23. Spang, A.E., P.J. Godowski, and D.M. Knipe. 1983. Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein. Journal of Virology 45:332-342.
  24. Quinlan, M.P. and D.M. Knipe. 1983. Nuclear localization of herpesviral proteins: Potential role of the cellular framework. Molecular and Cellular Biology 3:315-324.
  25. Lee, C.K. and D.M. Knipe. 1983. Thermolabile in vivo DNA-binding activity associated with a protein encoded by mutants of herpes simplex virus type 1. Journal of Virology 46:909-919.
  26. Godowski, P.J. and D.M. Knipe. 1983. Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression. Journal of Virology 47:478-486.
  27. Rafield, L.F. and D.M. Knipe. 1984. Characterization of the major mRNAs transcribed from the genes for glycoprotein gB and ICP8 DNA-binding protein of herpes simplex virus type 1. Journal of Virology 9:960-969.
  28. Quinlan, M.P., L.B. Chen, and D.M. Knipe. 1984. The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication. Cell 36:857-868.
  29. Knipe, D.M. 1985. "Molecular genetics of animal viruses," In Virology, B.N. Fields, ed. Raven Press, New York, N.Y. pp. 129-143.
  30. Quinlan, M.P. and D.M. Knipe. 1985. Stimulation of expression of a herpes simplex virus DNA-binding protein by two viral functions. Molecular and Cellular Biology 5:957-963.
  31. Quinlan, M.P. and D.M. Knipe. 1985. A genetic test for expression of a functional herpes simplex virus DNA-binding protein from a transfected plasmid. Journal of Virology 54:619-622.
  32. Lee, C.K. and D.M. Knipe. 1985. An immunoassay for the study of DNA-binding activities of the herpes simplex virus protein ICP8. Journal of Virology 54:731-738.
  33. Godowski, P.J. and D.M. Knipe. 1985. Identification of a herpes simplex virus function that represses late gene expression from parental viral genomes. Journal of Virology 55:357-365.
  34. Foster, C.S., R. Wetzig, D.M. Knipe, and M.I. Greene. 1985. Genetic influence from chromosome 12 on murine susceptibility to herpes simplex keratitis. In: Herpetic Eye Diseases, Dr. W. Junk Publishers, Dordrecht/Boston/Lancaster.
  35. Godowski, P.J. and D.M. Knipe. 1986. Transcriptional control of herpesvirus gene expression: Gene functions required for positive and negative regulation. Proc. Natl. Acad. Sci. U.S.A. 83:256-260.
  36. Knipe, D.M. and J.L. Smith. 1986. A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins. Molecular and Cellular Biology 6:2371-2381.
  37. Foster, C.S., Y. Tsai, J.G. Monroe, R. Campbell, M. Cestari, R. Wetzig, D.M. Knipe, and M.I. Greene. 1986. Genetic studies on murine susceptibility to herpes simplex keratitis. Clinical Immunology and Immunopathology 40:313-325.
  38. Sandstrom, I.K., C.S. Foster, P.A. Wells, D.M. Knipe, L.A. Caren, and M.I. Greene. 1986. Previous immunization of mice with herpes simplex virus type 1 strain MP protects against secondary corneal infection. Clinical Immunology and Immunopathology 40:326-334.
  39. Su, L. and D.M. Knipe, 1987. Mapping of the transcriptional initiation site of the herpes simplex virus type 1 ICP8 gene in infected and transfected cells. Journal of Virology 61:615-620.
  40. Knipe, D.M., D. Senechek, S.A. Rice, and J.L. Smith. 1987. Stages in the nuclear association of the herpes simplex virus transcriptional activator protein, ICP4. Journal of Virology 61:276-284.ff
  41. Gao, M., J. Bouchey, K. Curtin, and D.M. Knipe. 1988. Genetic identification of a portion of the herpes simplex virus ICP8 protein required for DNA-binding. Virology 163:319-329.
  42. Nabel, G.J., S.A. Rice, D.M. Knipe, and D. Baltimore. 1988. Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells. Science 239:1299-1302.
  43. Rice, S.A. and D.M. Knipe. 1988. Gene-specific transactivation by the herpes simplex virus type 1 alpha protein ICP27. Journal of Virology 62:3814-3823.
  44. de Bruyn Kops, A. and D.M. Knipe. 1988. Formation of DNA replication structures in herpes virus-infected cells requires a viral DNA binding protein. Cell 55:857-868.
  45. Leib, D.A., D.M. Coen, C.L. Bogard, K.A. Hicks, D.R. Yager, D.M. Knipe, K.L. Tyler, and P.A. Schaffer. 1989. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Journal of Virology 63:759-768.
  46. Su, L. and D.M. Knipe. 1989. Herpes simplex virus alpha protein ICP27 can inhibit or augment viral gene transactivation. Virology 170:496-504.
  47. Leib, D.A., C.L. Bogard, M. Kosz-Vnenchak, K.A. Hicks, D.M. Coen, D.M. Knipe, and P.A. Schaffer. 1989. A deletion mutant of the latency associated transcript (LAT) of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. Journal of Virology 63:2893-2900.
  48. Coen, D.M., M. Kosz-Vnenchak, J.G. Jacobson, D.A. Leib, C.L. Bogard, P.A. Schaffer, K.L. Tyler, and D.M. Knipe. 1989. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc. Natl. Acad. Sci. USA 86:4736-4740.
  49. Knipe, D.M. 1989. The role of viral and cellular nuclear proteins in herpes simplex virus replication. Advances in Virus Research 37:85-123. (PubMed)
  50. Rice, S.A., L. Su, and D.M. Knipe. 1989. Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities. Journal of Virology 63:3399-3407.
  51. Gao, M. and D.M. Knipe. 1989. Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein. Journal of Virology 63:5258-5267.
  52. Knipe, D.M. 1990. "Virus-host cell interactions." In Virology, 2nd ed. B.N. Fields and D.M. Knipe, eds. Raven Press, New York, NY, pp. 293-316.
  53. Rice, S.A. and D.M. Knipe. 1990. Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27. Journal of Virology 64:1704-1715.
  54. Kosz-Vnenchak, M., D.M. Coen, and D.M. Knipe. 1990. Restricted expression of herpes simplex virus lytic genes during establishment of latent infection by thymidine kinase-negative mutant viruses. Journal of Virology 64:5396-5402.
  55. Bush, M., D.R. Yager, M. Gao, K. Weisshart, A.I. Marcy, D.M. Coen, and D.M. Knipe. 1991. Correct intranuclear localization of the herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein. Journal of Virology 65:1082-1089.
  56. Gao, M. and D.M. Knipe. 1991. Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression. Journal of Virology 65:2666-2675.
  57. Gibbs, J.S., K. Weisshart, P. Digard, A. de Bruyn Kops, D.M. Knipe, and D.M. Coen. 1991. Polymerization activity of an alpha-like DNA polymerase requires a conserved 3'-5' exonuclease active site. Molecular and Cellular Biology 11:4786-4795.
  58. Thomas, M.S., M. Gao, D.M. Knipe, and K.L. Powell. 1992. Association between the herpes simplex virus major DNA-binding protein and alkaline nuclease. Journal of Virology 66:1152-1161.
  59. Gao, M. and D.M. Knipe. 1992. Distal protein sequences can affect the function of a nuclear localization signal. Molecular and Cellular Biology 12:1330-1339.
  60. Nguyen, L.H., D.M. Knipe, and R.W. Finberg. 1992. Replication-defective mutants of HSV induce cellular immunity and protect against lethal HSV infection. Journal of Virology 66:7067-7072.
  61. Gao, M. and D.M. Knipe. 1993. Intragenic complementation of herpes simplex virus ICP8 DNA-binding protein mutants. Journal of Virology 67: 876-885.
  62. Rice, S.A., V. Lam, and D.M. Knipe. 1993. The acidic amino-terminal region of herpes simplex virus type 1 alpha protein ICP27 is required for an essential lytic function. Journal of Virology 67:1778-1787.
  63. Kosz-Vnenchak, J. Jacobson, D.M. Coen, and D.M. Knipe. 1993. Evidence for a novel regulatory pathway for herpes simplex virus gene expression in trigeminal ganglion neurons. Journal of Virology 67:5383-5393.
  64. Curtin, K.D. and D.M. Knipe. 1993. Altered properties of the herpes simplex virus ICP8 DNA-binding protein in cells infected with ICP27 mutant viruses. Virology 196:1-14.
  65. Jacobson, J.G., K.L. Ruffner, M. Kosz-Vnenchak, C.B.C. Hwang, K.N. Wobbe, D.M. Knipe, and D.M. Coen. 1993. Herpes simplex virus thymidine kinase and specific stages of latency in murine trigeminal ganglia. Journal of Virology 67:6903-6908.
  66. Davar, G., M.F. Kramer, D. Garber, A.L. Roca, J.K. Anderson, W. Bebrin, D.M. Coen, M. Kosz-Vnenchak, D.M. Knipe, X.O. Breakfield, and O. Isascson. 1994. Comparative efficacy of gene delivery to mouse sensory neurons using herpesvirus vectors. Journal of Comparative Neurology 339:3-11.
  67. Morrison, L.A. and D.M. Knipe. 1994. Immunization with Replication-Defective Mutants of Herpes Simplex Virus Type 1: Sites of Immune Intervention in Pathogenesis of Challenge Virus Infection. Journal of Virology 68:689-696.
  68. Morrison, L.A. and D.M. Knipe. 1994. "Immunization using replication-defective mutants of hsv-1". In Vaccines 1994. Modern Approaches to New Vaccines Including Prevention of AIDS. E. Norrby, F. Brown, R.M. Chanock, and H.S. Ginsberg, eds. Cold Spring Harbor Laboratory Press, NY, pp. 361-365.
  69. Nguyen, L.H., D.M. Knipe, and R.W. Finberg. 1994. Mechanisms of virus-induced Ig subclass shifts. Journal of Immunology 152:478-484. (PubMed)
  70. de Bruyn Kops, A. and D.M. Knipe. 1994. Preexisting nuclear architecture defines the intranuclear location of herpesvirus DNA replication structures. Journal of Virology 68:3512-3526.
  71. Knipe, D.M., X. Da Costa, L.A. Morrison, N. Bourne, and L.R. Stanberry. 1995. "Immunization against genital herpes disease with a replication-defective mutant of HSV-2". In Vaccines 95. R.M. Chanock, F. Brown, H.S. Ginsberg, and E. Norrby, eds. Cold Spring Harbor Laboratory press, NY, pp. 369-373.
  72. Knipe, D.M. 1996. Virus-host-cell interactions. In: Virology, 3rd ed. B.N. Fileds, D.M. Knipe and P. M. Howley, eds. Lippincott-Raven Press, Philadelphia, PA, pp. 273-299.
  73. Ahmed, R., L.A. Morrison, and D.M. Knipe. 1996. Persistence of viruses. In: Virology, 3rd ed. B.N. Fields, D.M. Knipe and P.M. Howley, eds. Lippincott-Raven Press, Philadelphia, PA, pp. 219-249.
  74. Babu, J. S., J. Thomas, S. Kanangat, L.A. Morrison, D.M. Knipe, and B.T. Rouse. 1996. Viral replication is required for induction of ocular immunopathology by herpes simplex virus. Journal of Virology 70:101-107.
  75. Xia, K., D.M. Knipe, and N.A. DeLuca. 1996. Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication. Journal of Virology 70:1050-1060.
  76. Xia, K., N.A. DeLuca, and D.M. Knipe. 1996. Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4. Journal of Virology 70:1061-1071.
  77. Liptak, L.M., S.L. Uprichard, and D.M. Knipe. 1996. Functional Order of Assembly of Herpes Simplex Virus DNA Replication Proteins into Prereplicative Site Structures. Journal of Virology 70:1759-1767.
  78. Uprichard, S.L. and D.M. Knipe. 1996. Herpes Simplex Virus ICP27 Mutant Viruses Exhibit Reduced Expression of Specific DNA Replication Genes. Journal of Virology 70:1969-1980.
  79. Kanangat,S., J.S. Babu, D.M. Knipe, and B.T. Rouse. 1996. HSV-1 mediated modulation of cytokine gene expression in a permissive cell line: Selective upregulation of IL-6 gene expression. Virology 219:295-300.
  80. Knipe, D.M., X. Da Costa, and L.A. Morrison. 1996. "Immunization against genital herpes disease: Factors in the design of a replication-impaired vaccine." In: Vaccines 1996. F. Brown, E. Norrby, D. Burton, and J. Mekalanos, eds. Cold Spring Harbor Laboratory press, NY, pp. 13-17.
  81. Morrison, L.A. and D.M. Knipe. 1996. Mechanisms of immunization with a replication-defective mutant of herpes simplex virus 1. Virology 220:402-413.
  82. Brubaker, J.O., C.M. Thompson, L.A. Morrison, D.M. Knipe, G.R. Siber, and R.W. Finberg. 1996. Th1-associated immune responses to beta-galactosidase expressed by a replication-defective herpes simplex virus. Journal of Immunology 157:1598-1604. (PubMed)
  83. Chen, M. and D. M. Knipe. 1996. A dominant mutant form of the herpes simplex virus ICP8 protein decreases viral late gene transcription. Virology 221:281-290.
  84. Knipe, D.M. 1996. "The replication of herpes simplex virus". In: Genital and Neonatal Herpes. L.R. Stanberry, ed. John Wiley & Sons, Ltd., Chichester, England, pp. 1-29.
  85. Ahmed, R., L.A. Morrison, and D.M. Knipe. 1997. "Viral persistence". In: Viral Pathogenesis. N. Nathanson, R. Ahmed, F. Gonzalez-Scarano, D.E. Griffin, K.V. Holmes, F.A. Murphy, H.L. Robinson eds. Lippincott-Raven Publishers, Philadelphia, PA, pp. 181-205.
  86. Uprichard, S.L. and D.M. Knipe. 1997. Assembly of herpes simplex virus replication proteins at two distinct intranuclear sites. Virology 229:113-125.
  87. Brehm, M. A., R.H. Bonneau, D.M. Knipe, and S.S. Tevethia. 1997. Immunization with a replication deficient mutant of herpes simplex virus type 1 (HSV-1) induces a CD8+ cytotoxic T lymphocyte (CTL) response and confers a level of protection comparable to wild-type HSV-1. Journal of Virology 71:3534-3544.
  88. Da Costa, X.J., N. Bourne, L.R. Stanberry, and D.M. Knipe. 1997. Construction and characterization of a replication-defective herpes simplex virus 2 ICP8 mutant strain and its use in immunization studies in a guinea pig model of genital disease. Virology 232:1-12.
  89. Garber, D.A, P.A. Schaffer, and D.M. Knipe. 1997. A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1. Journal of Virology 71:5885-5893.
  90. Morrison, L.A. and D.M. Knipe. 1997. Contributions of antibody and T cell subsets to protection elicited by immunization with a replication-defective mutant of herpes simplex virus type 1. Virology 239:315-326.
  91. Kramer, M.F., S.-H. Chen, D.M. Knipe, and D.M. Coen. 1998. Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus. Journal of Virology 72:1177-1185.
  92. Morrison, L.A., X.J. Da Costa, and D.M. Knipe. 1998. Influence of mucosal and parenteral immunization with a replication-defective mutant of HSV-2 on immune responses and protection from genital challenge. Virology 243:178-187.
  93. Hann, L.E., W.J. Cook, S.L. Uprichard, D. M. Knipe, and D.M. Coen. 1998. The role of herpes simplex virus ICP27 in the regulation of UL24 gene expression by differential polyadenylation. Journal of Virology 72:7709-7714.
  94. de Bruyn Kops, A., S.L. Uprichard, M. Chen, and D.M. Knipe. 1998. Comparison of the intranuclear distributions of herpes simplex virus proteins involved in various viral functions. Virology 252:162-178.
  95. Hantman, M.J., E.L. Hohmann, C.G. Murphy, D.M. Knipe, and S.I. Miller. 1999. Antigen delivery systems: Development of recombinant live vaccines using viral or bacterial vectors. In: Mucosal Immunology, Second Edition. P.L. Ogra, J. Mestecky, M.E. Lamm, W. Strober, J.R. McGhee and J. Bienenstock, eds. Academic Press, San Diego, CA pp. 779-791.
  96. Da Costa, X.J., C.A. Jones, and D.M. Knipe. 1999. Immunization against genital herpes with a vaccine virus that has defects in productive and latent infection. Proceedings of the National Academy of Sciences, USA 96:6994-6998.
  97. Da Costa, X.J., M.A. Brockman, E. Alicot, M. Ma, M.B. Fischer, X. Zhou, D.M. Knipe, and M.C. Carroll. 1999. Humoral response to herpes simplex virus is complement-dependent. Proceedings of the National Academy of Sciences, USA 96:12708-12712.
  98. Song, B., J.J. Liu, K-C. Yeh, and D.M. Knipe. 2000. Herpes simplex virus infection blocks events in the G1 phase of the cell cycle. Virology 267:326-334.
  99. Murphy, C.G., W.T. Lucas, R. Means, S. Czajak, C.L. Hale, J.D. Lifson, A. Kauer, R.P. Johnson, D.M. Knipe, and R.C. Desrosiers. 2000. Vaccine protection against simian immunodeficiency virus by recombinant strains of herpes simplex virus. Journal of Virology 74:7745-7753.
  100. Da Costa, X.J., M.F. Kramer, J. Zhu, M.A. Brockman, and D.M. Knipe. 2000. Construction, phenotypic analysis and immunogenicity of a UL5/UL29 double deletion mutant of herpes simplex virus 2. Journal of Virology 74:7963-7971.
  101. McNamee, E.E., T.J. Taylor, and D.M. Knipe. 2000. A dominant-negative herpesvirus protein inhibits intranuclear targeting of viral proteins: Effects on DNA replication and late gene expression. Journal of Virology 74:10122-10131.
  102. Jones, C.A., T.J. Taylor, and D.M. Knipe. 2000. Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model. Virology 278:137-150.
  103. Chen, S.-H., D.A. Garber, P.A. Schaffer, D.M. Knipe, and D.M. Coen. 2000. Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation. Virology 278:207-216.
  104. Deshpande, S.P., S. Lee, M. Zheng, B. Song, D.M. Knipe, J.A. Kapp, and B.T. Rouse. 2001. Herpes simplex virus-induced keratitis: Evaluation of the role of molecular mimicry in lesion pathogenesis. Journal of Virology 75:3077-3088.
  105. Jean, S., K.M. LeVan, B. Song, M. Levine, and D.M. Knipe. 2001. Herpes simplex virus 1 ICP27 is required for transcription of two viral late (g2) genes in infected cells. Virology 283:273-284.
  106. Knipe, D.M., C.E. Samuel and P. Palese. 2001. Virus-Host Cell Interactions, Chapter 7. In: Fields Virology, Fourth Edition, D.M. Knipe, P.M. Howley et al., eds., Lippincott, Williams & Wilkins, Philadelphia, PA. pp. 133-170.
  107. Roizman, B. and D.M. Knipe. 2001. Herpes Simplex Viruses and Their Replication, Chapter 72. In: Fields Virology, Fourth Edition, D.M. Knipe, P.M. Howley et al., eds., Lippincott, Williams & Wilkins, Philadelphia, PA. pp. 2399-2459.
  108. Verschoor, A., M.A. Brockman, D.M. Knipe, and M.C. Carroll. 2001. Cutting edge: Myeloid complement C3 enhances humoral response to peripheral viral infection. Journal of Immunology 167:2446-2451.
  109. Da Costa, X.J., L.A. Morrison, and D.M. Knipe. 2001. Comparison of different forms of herpes simplex replication-defective mutant viruses as vaccines in a mouse model of HSV-2 genital infection. Virology 288:256-263.
  110. Song, B., K.-C. Yeh, J. Liu, and D.M. Knipe. 2001. Herpes simplex virus gene products required for viral inhibition of expression of G1 phase functions. Virology 290:320-328.
  111. Brockman, M. and D.M. Knipe. 2002. Herpes simplex virus vectors elicit durable immune responses in presence of preexisting host immunity. Journal of Virology. 76: 3678-3687.
  112. Taylor, T.J., M.A. Brockman, E.E. McNamee, and D.M. Knipe. 2002. Herpes Simplex Virus. Frontiers in Bioscience 7:March, 2002, D752-D764.
  113. Chen, S.-H., L.Y. Lee, D.A. Garber, P.A. Schaffer, D.M. Knipe, and D.M. Coen. 2002. Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. Journal of Virology 76:4764-4772.
  114. Zhou, C. and D.M. Knipe. 2002. Association of herpes simplex virus 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme. Journal of Virology 76:5893-5904.
  115. Gadjeva, M., A. Vershoor, M.A. Brockman, H. Jezak, L.-M. Shen, D.M. Knipe, and M.C. Carroll. 2002. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. The Journal of Immunology 169:5489-5495.
  116. Lucas, W.T. and D.M. Knipe. 2002. Viral capsids and envelopes: Structure and Function. Encyclopedia of Life Sciences. (PDF file)
  117. Mann, M.A., K. L. Tyler, D.M. Knipe, and B.N. Fields. 2002. Type 3 reovirus neuroinvasion after intramuscular inoculation: Viral genetic determinants of lethality and spinal cord infection. Virology 303:213-221.
  118. Mann, M.A., D.M. Knipe, G.D. Fischbach, and B.N. Fields. 2002. Type 3 reovirus neuroinvasion after intramuscular inoculation: Direct invasion of nerve terminals and age-dependent pathogenesis. Virology 303:222-231.
  119. Zhao, X., E. Deak, K. Soderberg, M. Linchen, D. Spezzano, J. Zhu, D.M. Knipe, and A. Iwasaki. 2003. Vaginal submucosal dendritic cells, but not Langerhan's cells, induce protective TH1 responses to herpes simplex virus 2. The Journal of Experimental Medicine 197:153-162.
  120. Taylor, T.J., E.E. McNamee, C. Day, and D.M. Knipe. 2003. Herpes simplex virus replication compartments can form by coalescence of smaller compartments. Virology 309:232-247.
  121. Taylor, T.J. and D.M. Knipe. 2003. C-Terminal region of herpes simplex virus ICP8 protein needed for intranuclear localization. Virology 309:219-231.
  122. Kramer, M.F., J. Riley, A.L. Spoering, D.M. Coen, and D.M. Knipe. 2003. Effect of immunization on herpes simplex virus type 1 latent infection in the trigeminal ganglion. Current Eye Research 26:185-194.
  123. Uprichard, S.L. and D.M. Knipe. 2003. Conformational changes in the herpes simplex virus ICP8 DNA-binding protein coincident with assembly in viral replication structures. Journal of Virology 77:7467-7476.
  124. Wakimoto, H., P.R. Johnson, D.M. Knipe, and E.A. Chiocca. 2003. Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Therapy 10:983-990.
  125. Knipe, D.M. 2003. Viral vaccines: Past, present and future. Medicina Universitaria 5:116-122.
  126. Kramer, M.F., W.J. Cook, F.R. Roth, J. Zhu, H. Holman, D.M. Knipe, and D.M. Coen. 2003. Latent herpes virus infection of sensory neurons alters neuronal gene expression. Journal of Virology 77:9533-9541.
  127. Verschoor, A., M.A. Brockman, M.A. Gadjeva, D.M. Knipe, and M.C. Carroll. 2003. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. Journal of Immunology 171:5363-5371.
  128. Jones, C.A. and D.M. Knipe. 2003. Herpes simplex virus vaccines. Pediatric Infectious Disease Journal 22:1003-1005. (PubMed)
  129. Pearson, A., D.M. Knipe, and D.M. Coen. 2004. ICP27 selectively regulates the cytoplasmic localization of a subset of viral transcripts in herpes simplex virus 1-infected cells. Journal of Virology 78:23-32.
  130. Kurt-Jones, E.A., M. Chan, S. Zhou, J. Wang, G. Reed, R. Bronson, M.M. Arnold, D.M. Knipe, and R.W. Finberg. 2004. Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. PNAS 101:1315-1320.
  131. Taylor, T.J. and D.M. Knipe. 2004. Proteomics of herpes simplex virus replication compartments: Association of cellular DNA replication, repair, recombination, and chromatin remodeling proteins with ICP8. Journal of Virology 78:5856-5866.
  132. Simpson-Holley, M., J. Baines, R. Roller, and D.M. Knipe. 2004. Herpes Simplex Virus 1 UL31 and UL34 Gene Products Promote the Late Maturation of Viral Replication Compartments to the Nuclear Periphery. Journal of Virology 78:5591-5600.
  133. Melroe, G., N. DeLuca, and D.M. Knipe. 2004. Herpes simplex virus 1 has multiple mechanisms for blocking virus-induced interferon production. Journal of Virology 78:8411-8420.
  134. Cook, W.J., R.M. Walker, T.J. Burwell, M.F. Kramer, H.A. Holman, D.M. Coen, and D.M. Knipe. 2004. Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection. Virology Journal, September 23, 2004.
  135. Fontaine-Rodriguez, E.C., T.J. Taylor, M. Olesky, and D.M. Knipe. 2004. Proteomics of herpes simplex virus infected cell protein 27: Association with translation initiation factors. Virology 330:487-492.
  136. Olesky, M., E.E. McNamee, C. Zhou, T.J. Taylor, and D.M. Knipe. 2005. Evidence for a direct interaction between HSV-1 ICP27 and ICP8 proteins. Virology 331:94-105.
  137. Kurt-Jones, E.A., J. Belko, C. Yu, P E. Newburger, J. Wang, M. Chan, D.M. Knipe, and R.W. Finberg. 2005. The role of toll like receptors in herpes simplex infection in neonates. Journal of Infectious Disease 191:746-748.
  138. Hoshino, Y., S.K. Dalai, K. Wang, L. Pesnicak, T.Y. Lau, D.M. Knipe, J.I. Cohen, and S.E. Straus. 2005. Comparative efficacy and immunogenicity of replication-defective, recombinant glycoprotein, and DNA vaccines for herpes simplex virus 2 infections in mice and guinea pigs. Journal of Virology 79:410-418.
  139. LaVail, J.H., A.N. Tauscher, J.W. Hicks, O. Harrabi, G.T. Melroe, and D.M. Knipe. 2005. Genetic and molecular in vivo analysis of herpes simplex virus assembly in murine visual system neurons. Journal of Virology 79:11142-11150.
  140. Simpson-Holley, M., R.C. Colgrove, G. Nalepa, J.W. Harper, and D.M. Knipe. 2005. Identification and functional evaluation of cellular and viral factors involved in the alteration of nuclear architecture during HSV-1 infection. Journal of Virology 79:12840-12851.
  141. Finberg, R.W., D.M. Knipe, and E.A. Kurt-Jones. 2005. Herpes simplex virus and Toll-like receptors. Viral Immunology 18:457-465.
  142. Wang, Q.-Y., C. Zhou, K.E. Johnson, R.C. Colgrove, D.M. Coen, and D.M. Knipe. 2005. Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection. Proceedings of the National Academy of Sciences, USA 102:16055-16059.
  143. Petit, C. M., J.M. Melancon, V.N. Chouljenko, R. Colgrove, M. Farzan, D.M. Knipe, and K.G. Kousoulas. 2005. Genetic analysis of the SARS-coronavirus spike glycoprotein functional domains involved in cell-surface expression and cell-to-cell fusion. Virology 341:215-230.
  144. Pesola, J. M., J. Zhu, D.M. Knipe, and D.M. Coen. 2005. Herpes simplex virus 1 immediate-early and early gene expression during reactivation from latency under conditions that prevent infectious virus production. Journal of Virology 79:14516-14525.
  145. Palliser, D., D. Chowdhury, Q.-Y. Wang, S.J. Lee, R.T. Bronson, D.M. Knipe, and J. Lieberman. 2006. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439:89-94.
  146. Dudek, T. and D.M. Knipe. 2006. Replication-defective viruses as vaccines and vaccine vectors. Virology 344:230-239.
  147. Brockman, M.A., A. Verschoor, J. Zhu, M.C. Carroll, and D.M. Knipe. 2006. Optimal long-term humoral responses to replication-defective herpes simplex virus require CD21/CD35 complement receptor expression on stromal cells. Journal of Virology 80:7111-7117.
  148. Orlando, J.S., J.W. Balliet, A.S. Kushnir, T.L. Astor, M. Kosz-Vnenchak, S.A. Rice, D.M. Knipe, and P.A. Schaffer. 2006. ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. Journal of Virology 80:9381-9390.
  149. Watanabe, D., M.A. Brockman, T. Ndung'u, L. Mathews, W. Lucas, C.G. Murphy, B.K. Felber, G.N. Pavlakis, N.A. DeLuca, and D.M. Knipe. 2006. Properties of a herpes simplex virus multiple immediate-early gene-deleted recombinant as a vaccine vector. Virology 357:186-198.
  150. Kaur, A., H.B. Sanford, D. Garry, S. Lang, S.A. Klump, D. Watanabe, R.T. Bronson, J.D. Lifson, M. Rosati, G.N. Pavlakis, B.K. Felber, D.M. Knipe, and R.C. Desrosiers. 2006. Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. Virology 357:199-214
  151. Melroe, G.T., L. Silva, P.A. Schaffer, and D.M. Knipe. 2007. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-β induction. Virology 360:305-321.
  152. Petit, C.M., V.N. Chouljenko, A. Iyer, R. Colgrove, M. Farzan, D.M. Knipe, and K.G. Kousoulas. 2007. Palmitoylation of the cysteine-rich endodomain of the SARS-coronavirus spike glycoprotein is important for spike-mediated cell fusion. Virology 360:264-274.
  153. Roizman, B., D.M. Knipe, and R. Whitley. 2007. "Herpes Simplex Viruses" In: Fields Virology, Fifth Edition, D.M. Knipe, P.M. Howley et al., eds., Lippincott, Williams & Wilkins, Philadelphia, PA, pp. 2501-601.
  154. Whitley, R.J., A. Arvin, J.I. Cohen, L. Correy, D.M. Knipe, and H. Masur. 2007. A Tribute to Stephen E. Straus, M.D. (1946-2007). The Journal of Infectious Diseases 196:963-4.
  155. Dodson, A.W., T.J. Taylor, D.M. Knipe, and D.M. Coen. 2007. Inhibitors of the sodium potassium ATPase that impair herpes simplex virus replication identified via a chemical screening approach. Virology 366:340-8.
  156. van Lint, A.L., E. Torres-Lopez, and D.M. Knipe. 2007. Immunization with a replication-defective herpes simplex virus-2 mutant reduces herpes simplex virus-1 infection and prevents ocular disease. Virology 368:227-31.
  157. Dudek, T., L. Mathews, and D.M. Knipe. 2007. Disruption of the UL41 Gene in the Herpes simplex virus 2 dl5-29 mutant increases its immunogenicity and protective capacity in a murine model of genital herpes. Virology 372:165-75.
  158. Fontaine-Rodriguez, E.C. and D.M. Knipe. 2007. Herpes Simplex Virus ICP27 Increases Translation of a Subset of Viral Late mRNAs. Journal of Virology 82:3538-45.
  159. Johnson, K.E., B. Song, and D.M. Knipe. 2008. Role for herpes simplex virus 1 ICP27 in the inhibition of type I interfereon signaling. Virology 374:487-94.
  160. Knipe, D.M., A. Cliffe. 2008. Chromatin control of herpes simplex virus lytic and latent infection. Nature Reviews: Microbiology 6:211-21.
  161. Silva, L., A.R. Cliffe, L. Chang, and D.M. Knipe. 2008. Role for A-Type Lamins in Herpesviral DNA Targeting and Heterochromatin Modulation. PLoS Pathogens 4:(e1000071)1-10.
  162. Liu, X. and D.M. Knipe. 2008. Herpesvirus Structural Protein Activates NF-κB Signaling through the TRAF-6 Adaptor Protein. Proceedings of the National Academy of Sciences, USA 105:11335-9.
  163. Hoshino, Y., L. Pesnicak, K.C. Dowdell, J. Lacayo, T. Dudek, D.M. Knipe, S.E. Straus, and J.I. Cohen.  2008.  Comparison of immunogenicity and protective efficacy of genital herpes vaccine candidates herpes simplex virus 2 dl5-29 and dl5-29-41L in mice and guinea pigs.  Vaccine 26:4034-40.
  164. Cliffe, A.R. and D.M. Knipe.  2008.  Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection.  Journal of Virology 82:12030-8.
  165. Hamirally, S., J.P. Kamil, Y.M. Ndassa-Colday, A.J. Lin, W.J. Jahng, M.-C. Baek, S. Noton, L. Silva, M. Simpson-Holley, D.M. Knipe, D.E. Golan, J.A. Marto, and D.M. Coen.  2008, Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress.  PloS Pathogens 5:(e1000275)1-12.
  166. Brockman, M.A and D.M. Knipe. 2008.  Herpes simplex virus as a tool to define the role of complement in the immune response to peripheral infection. Vaccine 26:194-9.
  167. Lint, A.L. and D.M. Knipe.  2009.  “Herpespviruses”  In: Encyclopedia of Microbiology, M. Schaechter editor, Elsevier, Oxford, pp. 376-90.
  168. Taylor, T.J. and D.M. Knipe.  2009.  The use of green fluorescent fusion proteins to monitor herpes simplex virus replication.  Methods of Molecular Biology 515:239-48.
  169. Liu, X., E. Broberg, D. Watanabe, T. Dudek, N. DeLuca, and D.M. Knipe. 2009.  Genetic engineering of a modified herpes simplex virus 1 vaccine vector.  Vaccine 27:2760-7.
  170. Cliffe, A.R., D.S. Garber, and D.M. Knipe.  2009. Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterchromtain on the latent genome. Journal of Virology 83:8182-90.
  171. Hoshino, Y., L. Pesnicak, K.C. Dowdell, P.D. Burbelo, D.M. Knipe, S.E. Straus, and J.I. Cohen.  2009.  Protection from herpes simplex virus (HSV)-2 infection with replication-defective HSV-2 or glycoprotein D2 vaccines in HSV-1-seropositive and HIV-1-seronegative guinea pigs.  Journal of Infectious Diseases 7:1088-95.
  172. Johnson, K.E. and D.M. Knipe.  2010.  HSV-1 infection causes the secretion of a type I interferon-antagonizing protein and inhibits signaling at or before Jak-1 activation.  Virology 396:21-9.
  173. Hancock, M.H., A.R. Cliffe, D.M. Knipe, and J.R. Smiley.  2010.  Herpes simplex virus VP16, but not ICP0, is required to reduce histone occupancy and enhance histone acetylation on viral genomes in U2OS Osteosarcoma cells. Journal of Virology 84:1366-75
  174. Reszka, N., C. Zhou, B. Song, J.G. Sodroski, and D.M. Knipe.  2010.  Simian TRIM5a Proteins Reduce Replication of Herpes Simplex Virus.  Virology 398:243-50.
  175. Reszka, N.J., T. Dudek, and D.M. Knipe.  2010.  Construction and Properties of a Herpes Simplex Virus 2 dl5-29 Vaccine Candidate Strain Encoding an HSV-1 Virion Host Shutoff Protein.  Vaccine 28:2754-62.
  176. Jurak, I., M.F. Kramer, J.C. Mellor, A.L. van Lint, F.P. Roth, D.M. Knipe, and D.M. Coen.  2010.  Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2.  Journal of Virology 84:4659-72.
  177. Zhou S., A.M. Cerny, G. Bowen, M. Chan, D.M. Knipe, E.A. Kurt-Jones, and R.W. Finberg.  2010.  Discovery of a novel TLR2 signaling inhibitor with anti-viral activity.  Antiviral Research 87:295-306.
  178. van Lint, A.L., M.R. Murawski, R.E. Goodbody, M. Severa, K.A. Fitzgerald, R.W. Finberg, D.M. Knipe, and E.A. Kurt-Jones.  2010.  Herpes simplex virus immediate-early ICP0 protein inhibits TLR2-dependent inflammatory responses and NF-κB signaling.  Journal of Virology 84:10802-11.
  179. Knipe, D.M.  2011.  Replication-defective herpes simplex virus mutant strains as genital herpes vaccines and vaccine vectors.  In:  Replicating vaccines:  A new generation,  R. Rappuoli, C. Mandl and P. Dormitzer, eds.  Birkhauser Verlag, The Netherlands, pp. 285-298.
  180. Dudek, T.E. and D.M. Knipe.  2011.  Vaccine and new antiviral strategies against herpes simplex virus.  In:  Alpha herpesviruses:  Molecular Virology, S. Weller, editor,  Caister Academic Press, Norfolk, UK, pp. 317-350.
  181. Bryant, K., R. Colgrove, and D.M. Knipe.  2011. Cellular SNF2H Chromatin-Remodeling Factor Promotes Herpes Simplex Virus 1 Immediate-Early Gene Expression and Replication.  mBio 2:e00330-10. 
  182. Dudek, T.E., E. Torres-Lopez, C. Crumpacker, and D.M. Knipe.  2011. Evidence for differences in immunological and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. Journal of Infectious Diseases 203:1434-41 & erratum
  183. Chang, L., W.J. Godinez, I.-H. Kim, M. Tektonidis, P. deLanerolle, R. Eils, K. Rohr, and D.M. Knipe.  2011. PNAS Plus:  Herpesviral replication compartments move and coalesce at nuclear speckles to enhance viral late mRNA export. Proceedings of the National Academy of Sciences, USA 108:E136-44.
  184. Rao, P., H.T. Pham, A. Kulkarni, Y. Yang, X. Liu, D.M. Knipe, P. Cresswell, and W. Yuan.  2011.  Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function.  Journal of Virology 85:8093-104.
  185. Kramer, M., I. Jurak, J.M. Pesola, S. Boissel, D.M. Knipe, and D.M. Coen.  2011. Herpes simplex virus 1 microRNAs expressed abundantly during latent infection are not essential for latency in mouse trigeminal ganglia.  Virology 417:239-47.
  186. Strang, B. L., S. Boulant, L. Chang, D.M. Knipe, T. Kirchhausen, and D.M. Coen.  2012.  Human cytomegalovirus UL44 concentrates at the periphery of replication compartments, the site of viral DNA synthesis. Journal of Virology 86:2089-95.
  187. Silva, L., H.S. Oh, L. Chang, Z. Yan, S.J. Triezenberg, and D.M. Knipe. 2012. Role for the nuclear lamina in stable nuclear association and assembly of a herpesviral transactivator complex on viral immediate-early genes.  mBio 3:00300-11.
  188. Wang, J.P., G.N. Bowen, S. Zhou, A. Cerny, A. Zacharia, D.M. Knipe, R.W. Finberg, and E.A. Kurt-Jones.  2012.  Role of specific innate immune responses in herpes simplex virus infection of the central nervous system. Journal of Virology 86:2273-81.
  189. Barczak, A.K., J.E. Gomez, B.B. Kaufmann, E.R. Hinson, L. Cosimi, M. Borowsky, A.B. Onderdonk, S.A. Stanley, D. Kaur, K.F. Bryant, D.M. Knipe, A. Sloutsky, and D.T. Hung.  2012.  RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proceedings of the National Academy of Sciences, USA 109:6217-22.
  190. Bryant, K.F., Z. Yan, D.H. Dreyfus, and D.M. Knipe.  2012.  Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication.  Journal of Virology 86:6825-34.
  191. Cliffe, A.R. and D.M. Knipe.  2012. “Chromatin Structure of the Herpes Simplex Virus 1 Genome during Lytic and Latent Infection”  In: From the Hallowed Halls of Herpesvirology:  A Review Series Commemorating the 80th Birthday of Bernard Roizman, Sc.D., J.A. Blaho and J.D. Baines editors, World Scientific Publishing/ Imperial College Press, City, pp. 93-122.
  192. Soberman, R.J., C.R. McKay, C.A. Vaine, G.B. Ryan, A.M. Cerny, M.R. Thompson, B. Nikolic, V. Primo, P. Christmas, P. Sheiffel, L. Aranov, D.M. Knipe, and E.A. Kurt-Jones.  2012.  CD200R1 licenses pro-inflammatory signaling and functions of TLR2. PLOS ONE 7:e47440.
  193. Orzalli, M.H., N.A. DeLuca, and D.M. Knipe.  2012. Nuclear IFI16 induction of IRF-3 Signaling during herpesviral infection:  Degradation of IFI16 by nuclear HSV ICP0 protein. Proceedings of the National Academy of Sciences USA 109:E3008-17.
  194. Lee, M.N., M. Roy, S.E. Ong, P. Mertins, A.C. Villani, W. Li, F. Dotiwala, J. Sen, J.G. Doench, M.H. Orzalli, I. Kramnik, D.M. Knipe, J. Lieberman, S.A. Carr, and N. Hacohen.  2013.  Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.  Nature Immunology 14:179-85.
  195. Larson, A.M., H.S. Oh, D.M. Knipe, and A.M. Klibanov.  2013.  Decreasing herpes simplex viral infectivity in solution by surface-immobilized and suspended N,N-Dodecyl,methyl-polyethylenimine. Pharmaceutical Research 30:25-31.
  196. Knipe, D.M., P.M. Lieberman, J.U. Jung, A.A. McBride, K.V. Morris, M. Ott, D. Margolis, A. Nieto, M. Nevels, R.J. Parks, and T.M. Kristie.  2013.  Snapshots:  Chromatin control of viral infection. Virology 435:141–156.
  197. Cliffe, A.R., D.M. Coen, and D.M. Knipe.  2013.  Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex virus genome during the establishment of latent infection. mBio 4:e00590-12.
  198. Sen, J., X. Liu, R. Roller, and D.M. Knipe.  2013.  Herpes simplex virus US3 tegument protein inhibits toll-like receptor 2 signaling at or before TRAF6 ubiquitination. Virology 439:65-73.
  199. Roizman, B., D.M. Knipe, and R. Whitley.  2013.  “Herpes Simplex Viruses,” in Fields Virology, 6th edition.  Lippincott Williams and Wilkins, Philadelphia, PA.  pp. 1823-1897.
  200. Orzalli, M.H., S.E. Conwell, C. Berrios, J.A. Decaprio, and D.M. Knipe.  2013.  Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.  Proc. Nat. Acad. Sci. USA. 110(47):E4492-501.
  201. Colgrove, R., F. Diaz, R. Newman, S. Saif, T. Shea, S. Young, M. Henn, and D.M. Knipe.  2014.  Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.  Virology 450-451:140-145.
  202. Bonham, K.S., M.H. Orzalli, K. Hayashi, A.I. Wolf, C. Glanemann, W. Weninger, A. Iwasaki, D.M. Knipe, and J.C. Kagan.  2014.  A promiscuous lipid-binding domain protein diversifies the subcellular sites of Toll-like recepter signal transduction.  Cell 156:705-716.
  203. Oh, H.S., K.F. Bryant, T.J.F. Nieland, A. Mazumder, Mukta Bagul, M. Bathe, D.E. Root, and D.M. Knipe.  2014.  Targeted RNAi Screen Reveals Novel Epigenetic Factors that Regulate Herpesviral Gene Expression.  mBio 5:e01086-13. 
  204. Orzalli, M.H. and D.M. Knipe.  2014.  Cellular Sensing of Viral DNA and Viral Evasion Mechanisms.  Annual Reviews of Microbiology 68:477-492.
  205. Cliffe, A.R., L. Chang, R. Colgrove, and D.M. Knipe.  2013.  “Herpes Simplex Virus.”  In Encyclopedia of Human Biology, 3rd edition.  Elsevier, Oxford, UK.
  206. van Lint, A.L. and D.M. Knipe.  2014.  Herpesviruses.  Online Reference Module in Biomedical Sciences.  Elsevier.
  207. Knipe, D.M., L. Corey, J.I. Cohen, and C.D. Deal.  2014.  Summary and Recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) Workshop on “Next Generation Herpes Simplex Virus Vaccines.”  Vaccine 32:1561-1562.
  208. Yan, Z., K.F. Bryant, S.M. Gregor, M. Angelova, D.H. Dreyfus, X.Z. Zhao, D.M. Coen, T.R. Burke, and D.M. Knipe.  2014.  HIV Integrase Inhibitors Block Replication of Alpha-, Beta-, and Gammaherpesviruses.  mBio 5:e01318-14.
  209. Thompson, M.R., S. Sharma, M. Atianand, S.B. Jensen, S. Carpenter, D.M. Knipe, K.A. Fitzgerald, and E.A. Kurt-Jones.  2014.  Interferon Gamma Inducible Protein (IFI)16 Transcriptionally Regulates Type I Interferons and other Interferon Stimulated Genes and Controls the Interferon Response to both DNA and RNA Viruses.  Journal of Biological Chemistry 289:23568-23581.
  210. Hill, J.M., D.C. Quenelle, R.D. Cardin, J.L. Vogel, C. Clement, F.J. Bravo, T.P. Foster, M. Bosch-Marce, P. Raja, J.S. Lee, D.I. Bernstein, P.R. Krause, D.M. Knipe, and T.M. Kristie.  2014.  Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression viral genomes.  Science Translational Medicine 6:265ra169.
  211. Deng, Z., E.T. Kim, O. Vladimirova, J. Dheekollu, Z. Wang, A. Newhart, D. Liu, J.L. Myers, S.E. Hensley, J. Moffat, M. Janicki, N.W. Fraser, D.M. Knipe, M.D. Weitzman, and P.M. Lieberman.  2014.  HSV-1 Remodels Host Telomeres to Facilitate Viral Replication.  Cell Reports 9:2263-78.
  212. Conwell, S.E., A.E. White, J.W. Harper, and D.M. Knipe.  2015.  Identification of TRIM27 as a Novel Degradation Target of Herpes Simplex Virus 1 ICP0.  Journal of Virology 89: 220-229.
  213. Hendricks, G.L., L. Velazquez, S. Pham, N. Qaisar, J.C. Delaney, K. Viswanathan, L. Albers, J.C. Comolli, Z. Shriver, D.M. Knipe, E.A. Kurt-Jones, D.K. Fygenson, J.M. Trevejo, J.P. Wang, and R.W. Finberg.  2015.  Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.  Antiviral Research 116:34-44.
  214. Knipe, D.M.  2015.  Nuclear Sensing of Viral DNA, Epigenetic Regulation of Herpes Simplex Virus Infection, and Innate Immunity.  Virology 479-480:153-159.
  215. Orzalli, M.H., N.M. Broekema, B.A. Diner, D.C. Hancks, N.C. Elde, I.M. Cristea, and D.M. Knipe.  2015.  cGAS-Mediated Stabilization of IFI16 Promotes Innate Signaling During Herpes Simplex Virus Infection.  Proc. Natl. Acad. Sci. USA 112(14):E1773-81.
  216. Oh, H.S. and D.M. Knipe.  2015.  Proteomic Analysis of the Herpes Simplex Virus 1 Virion Protein 16 Transactivator Protein in Infected Cells.  Proteomics 15:1957-67.
  217. Oh, H.S., P. Traktman, and D.M. Knipe.  2015.  Barrier-to-Autointegration-Factor 1 (BAF/BANF1) Promotes Association of the SETD1A Histone Methyltransferase with Herpes Simplex Virus Immediate-Early Gene Promoters.  mBio 6:e00345-15.
  218. Knipe, D.M. and S.P. Whelan.  2015.  Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era – A Conference at Harvard Medical School.  Journal of Virology 89:7446-8.
  219. Lamers, S.L., R.M. Newman, O. Laeyendecker, A.A.R. Tobian, R.C. Colgrove, S.C. Ray, D.M. Koelle, J.I. Cohen, D.M. Knipe, and T.C. Quinn.  2015.  Global Diversity Within and Between Human Herpes Virus 1 and 2 Glycoproteins.  Journal of Virology 89:8206-18.
  220. Newman, R.M., S.L. Lamers, B. Weiner, S.C. Ray, R.C. Colgrove, F. Diaz, L. Jing, K. Wang, S. Saif, S. Young, M. Henn, O. Laeyendecker, A.A.R. Tobian, J.I. Cohen, D.M. Koelle, T.C. Quinn, and D.M. Knipe.  2015.  Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.  Journal of Virology 89:8219-32.
  221. Angelova, M., R.F. Ortiz-Meoz, S. Walker, and D.M. Knipe.  2015.  Inhibition of O-linked N-acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.  Journal of Virology 89:8474-83.
  222. Thomann, S., J.B. Boscheinen, K. Vogel, D.M. Knipe, N. DeLuca, S. Gross, B. Schuler-Thurner, P. Schuster, and B. Schmidt.  2015. Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 (HSV-1) and plasmacytoid dendritic cells against tumor cells.  Immunology 146:327-38. 
  223. Knipe, D.M., P. Raja, and J.S. Lee.  2015. Clues to mechanisms of herpesviral latent infection and potential cures.  Proc. Natl. Acad. Sci. USA 112(39):11993-4.
  224. Colgrove, R.C., X. Liu, A. Griffiths, P. Raja, N.A. Deluca, R.M. Newman, D.M. Coen, and D.M. Knipe.  2016.  History and Genomic Sequence Analysis of the Herpes Simplex Virus 1 KOS and KOS1.1 Sub-Strains.  Virology 487:215-221.
  225. Diaz, F.M. and D.M. Knipe.  2016.  Protection from Genital Herpes Disease, Seroconversion, and Latent Infection in a Non-lethal Murine Genital infection Model by Immunization with an HSV-2 Replication-Defective Mutant Virus.  Virology 488:61-67.
  226. Lee, J.S., P. Raja, and D.M. Knipe.  2016.  Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.  mBio 7:e02007-15.
    • Commentary on this paper in:  Kristie, T.M.  2016.  Chromatin Modulation of Herpesvirus Lytic Gene Expression: Managing Nucleosome Density and Heterochromatic Histone Modifications.  mBio 7:e00098-16.
  227. Raja, P., J.S. Lee, D. Pan, J.M., D.M. Coen, and D.M. Knipe.  2016.  A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.  mBio 7: e00633-16.
  228. Christensen, M.H., S.B. Jensen, J.J. Miettinen, S. Luecke, T. Prabakaran, L.S. Reinert, T. Mettenleiter, Z.J. Chen, D.M. Knipe, R.M. Sandri-Goldin, L.W. Enquist, R. Hartmann, T.H. Hogensen, S.A. Rice, T.A. Nyman, S. Matikainen, and S.R. Paludan.  2016.  HSV-1 ICP27 Targets the BK1-Activated STING Signalsome to Inhibit Virus-Induced Type I IFN Expression.  EMBO Journal 35:1385-99.
  229. Taylor, T.J, F. Diaz, R.C. Colgrove, K.A. Bernard, N.A. DeLuca, S.P.J. Whelan, and D.M. Knipe.  2016.  Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.  Virology 496:186-193.
  230. Orzalli, M.H., N.M. Broekema, and D.M. Knipe.  2016.  Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types.  Journal of Virology 90:8351-8359.
  231. Zhao, J., Y. Zeng, S. Xu, J. Chen, G. Shen, C. Yu, D.M. Knipe, W. Yuan, J. Peng, W. Xu, C. Zhang, Z. Xia, and P. Feng.  2016.  A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation.  Cell Host & Microbe 20:1-15.
  232. Kurt-Jones, E.A., M.H. Orzalli, and D.M. Knipe.  2017.  Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.  Advances in Anatomy, Embryology and Cell Biology 223:49-75.
  233. Knipe, D.M., P. Raja, and J. Lee.  2017.  Viral gene products actively promote latent infection by epigenetic silencing mechanisms.  Current Opinion in Virology 23:68-74.
  234. Peng, T., S. Chanthaphavong, S. Sun, J. Trigilio, K. Phasouk, L. Jin, E. Layton, A. Li, C. Correnti, W. De van der Schueren, J. Vazquez, D. O'Day, I. Glass, D.M. Knipe, A. Wald, L. Corey, and J. Zhu.  2017.  Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.  The Journal of Experimental Medicine 214:2315-2329.
  235. Manivanh, R., J. Mehrbach, D.M. Knipe, and D.A. Leib.  2017.  The Role of Herpes Simplex Virus Type 1 γ34.5 in the Regulation of IRF3 Signaling.  Journal of Virology 91:e01156-17.
  236. Hoyos-Bachiloglu, R., J. Chou, C.N. Sodroski, A. Beano, W. Bainter, M. Angelova, E. Alldrissi, M.K. Habazi, H.A. Alghamdi, F. AlManjomi, M. AlShehri, N. Elsidig, M. Alaaeldin, D.M. Knipe, M. AlZahrani, and R.S. Geha.  2017.  A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.  Journal of Clinical Investigation 127:4415-4420.
  237. Diaz, F., S. Gregory, H. Nakashima, M.S. Viapiano, and D.M. Knipe.  2018.  Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.  Virology 513:129-135.
  238. Lee, J.S., P. Raja, D. Pan, J.M. Pesola, D.M. Coen, and D.M. Knipe.  2018.  CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.  mBio 9:e02372-1.
  239. Merkl, P.E., M.H. Orzalli, and D.M. Knipe.  2018.  Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication.  Journal of Virology 92:e00057-18.
  240. Su. Z., S.A. Dziedzic, D. Hu, V.J. Barrett, N.M. Broekema, W. Li, L. Qian, N. Jia, D. Ofengeim, A. Najafov, H. Zhu, D.M. Knipe, and J. Yuan.  2018.  ABIN-1 heterozygocity sensitizes to innate immune response in both RIPK1-dependent and independent manner.  Cell Death and Differentiation 26:1077-1088.
  241. Chen Y., S. Sharma, P.A. Assis, Z. Jiang, R. Elling, A.J. Olive, S. Hang, J. Bernier, J.R. Huh, C.M. Sassetti, D.M. Knipe, R.T. Gazzinelli, and K.A. Fitzgerald.  2018.  CNBP controls IL-12 gene transcription and Th1 immunity.  Journal of Experimental Medicine 215:3136-3150.
  242. Cabral, J.M., H.S. Oh, and D.M. Knipe.  2018.  ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress. eLife 7:e40228.
  243. Zmasek, C.M., D.M. Knipe, P.E. Pellett, and R.H. Scheuermann.  2019.  Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO).  Virology 529:29-42.
  244. Merkl, P.E. and D.M. Knipe.  2019.  Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection. mBio 10:e02621-18.
  245. Boscheinen, J.B., S. Thomann, D.M. Knipe, N. DeLuca, B. Schuler-Thurner, S. Gross, J. Dörrie, N. Schaft, C. Bach, A. Rohrhofer, M. Werner-Klein, B. Schmidt, and P. Schuster.  2019.  Generation of an oncolytic herpes simplex virus 1 expressing human MelanA.  Frontiers in Immunology 10:2.
  246. Pan, D., G. Li, J. Morris-Love, S. Qi, L. Feng, M.E. Mertens, I. Jurak, D.M. Knipe, and D.M. Coen.  2019.  Herpes Simplex Virus-1 Lytic Infection Blocks miRNA Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.  mBio 10:e02856-18.
  247. Patel, C.D., I. Backes, S.A. Taylor, Y. Jiang, J.M. Pesola, D.M. Coen, D.M. Knipe, M.E. Ackerman, and D.A. Leib.  2019.  Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.  Science Translational Medicine 11:eaau6039 & supplement.
  248. Claiborne, D.T., T.E. Dudek, C.R. Maldini, K.A. Power, M. Ghebremichael, E. Seung, E.F. Mellors, V.D. Vrbanac, K. Krupp, A. Bisesi, A.M. Tager, D.M. Knipe, C.L. Boutwell, and T.M. Allen.  2019.  Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Actue HIV-1 Viremia.  Journal of Virology 93: e00814-19.
  249. Oh, H.S., W.M. Neuhausser, P. Eggan, M. Angelova, R. Kirchner, K.C. Eggan, and D.M. Knipe.  2019.  Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9.  eLife 8: e51662.
  250. Crowley, S.J., P.T. Bruck, M.A. Bhuiyan, A. Mitchell-Gears, M.J. Walsh, K. Zhangxu, L.R. Ali, H.-J. Jeong, J.R. Ingram, D.M. Knipe, H.L. Ploegh, M. Dougan, and S.K. Dougan.  2020.  Neoleukin-2 enhances anti-tumor immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH.  Open Biology 10:190235.
  251. Aschner, C.B., D.M. Knipe, and B.C. Herold.  2020.  Model of vaccine efficacy against HSV-2 superinfection of HSV-1 seropositive mice demonstrates protection by antibodies mediating cellular cytotoxicity.  npj Vaccines 5:35.
  252. Aschner, C.B., C. Pierce, D.M. Knipe, and B.C. Herold.  2020.  Vaccination Route as a Determinant of Protective Antibody Responses against Herpes Simplex Virus.  Vaccines 8:277.
  253. Neuhausser, W.M., H.S. Oh, P. Eggan, M. Angelova, R. Kirchner, K.C. Eggan, and D.M. Knipe.  2020.  Screening Method for CRISPR/Cas9 Inhibition of a Human DNA Virus: Herpes Simplex Virus.  Bio-protocol 10(17):e3748.
  254. Knipe, D.M., O. Levy, K.A. Fitzgerald, and E. Mühlberger.  2020.  Ensuring Vaccine Safety.  Science 370:1274-5.
  255. Reddi, T.S., P.E. Merkl, S.-Y. Lim, N.L. Letvin, and D.M. Knipe.  2021.  Tripartite Motif 22 (TRIM22) Protein Restricts Herpes Simplex Virus 1 by Epigenetic Silencing of Viral Immediate-Early Genes.  PLoS Pathogens 17:e1009281.
  256. Mertens, M.E. and D.M. Knipe.  2021.  Herpes Simplex Virus 1 Manipulates Host Cell Anti-viral and Pro-viral DNA Damage Responses.  mBio 12:e03552-20.
  257. Cabral, J.M., C.H. Cushman, C.N. Sodroski, and D.M. Knipe.  2021.  ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection.  PLOS Pathogens 17:e1009567.
  258. Sun, B., X. Yang, F. Hou, X. Yu, Q. Wang, H.S. Oh, P. Raja, J.M. Pesola, E.A.H. Vanni, S. McCarron, J. Morris-Love, A.H.M. Ng, G.M. Church, D.M. Knipe, D.M. Coen, and D. Pan.  2021.  Regulation of Host and Virus Genes by Neuronal miR-138 Favours Herpes Simplex Virus-1 Latency.  Nature Microbiology 6:682-696.
  259. Knipe, D.M. and R. Whitley.  2021.  Herpes Simplex Virus 1 and 2 (Herpesviridae).  In: Encyclopedia of Virology, 4th ed. Vol. 2.  D.H. Bamford and M. Zuckerman, eds.  Academic Press: Cambridge, MA. pp. 404–413.
  260. Kurt-Jones, E.A., T.E. Dudek, D. Watanabe, L. Mandell, J. Che, S. Zhou, L. Cao, T. Greenough, G.J. Babcock, F. Diaz, H.S. Oh, C. Zhou, R.W. Finberg, and D.M. Knipe.  2021.  Expression of SARS coronavirus 1 spike protein from a herpesviral vector induces innate immune signaling and neutralizing antibody responses.  Virology 559:165-172.
  261. Kaugars, K., J. Dardick, A.P. de Oliveira, K.A. Weiss, R. Lukose, J. Kim, L. Leung, S. Rajagopalan, S. Wolin, L. Akabas, D.M. Knipe, G. Bajic, and W.R. Jacobs Jr.  2021.  A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.  Proceedings of the National Academy of Sciences USA 118:e2110714118.
  262. Stubbs, S.H., M. Cornejo Pontelli, N. Mishra, C. Zhou, J. de Paula Sousa, R.M. Mendes Viana, W.I. Lipkin, D.M. Knipe, E. Arruda, and S.P.J. Whelan.  2021.  Vesicular Stomatitis Virus Chimeras Expressing the Oropouche Virus Glycoproteins Elicit Protective Immune Responses in Mice.  mBio 12:e0046321.
  263. Peng, T., K. Phasouk, C.N. Sodroski, S. Sun, Y. Hwangbo, E.D. Layton, L. Jin, A. Klock, K. Diem, A.S. Magaret, L. Jing, K. Laing, A. Li, M.-L. Huang, M. Mertens, C. Johnston, K.R. Jerome, D.M. Koelle, A. Wald, D.M. Knipe, L. Corey, and J. Zhu.  2021.  Tissue-Resident-Memory CD8+ T Cells Bridge Innate Immune Responses in Neighboring Epithelial Cells to Control Human Genital Herpes.  Frontiers in Immunology 12:735643.
  264. Knipe, D.M., E.E. Heldwein, I.J. Mohr, and C.N. Sodroski.  2021.  Herpes Simplex Viruses: Mechanisms of Lytic and Latent Infection.  In: Fields Virology, 7th ed. Vol. 2: DNA Viruses.  D.M. Knipe and P.M. Howley, eds.  Lippincott Williams and Wilkins, Philadelphia, PA. pp. 235-296.
  265. Leon, J., D.A. Michelson, J. Olejnik, K. Chowdhary, H.S. Oh, A.J. Hume, S. Galván-Peña, Y. Zhu, F. Chen, B. Vijaykumar, L. Yang, E. Crestani, L.M. Yonker, E. Mühlberger, D.M. Knipe, and C. Benoist.  2022.  A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface.  Proceedings of the National Academy of Sciences USA 119:e2116853118.
  266. van Gent, M., J.J. Chiang, S. Muppala, C. Chiang, W. Azab, L. Kattenhorn, D.M. Knipe, N. Osterrieder, and M. Gack.  2022.  The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I to Suppress Innate Immunity.  J Virol 96:e0151021.
  267. Knipe, D.M., A. Prichard, S. Sharma, and J. Pogliano.  2022.  Replication Compartments of Eukaryotic and Bacterial DNA Viruses: Common Themes Between Different Domains of Host Cells.  Annu Rev Virol 9:307-327.
  268. Knipe, D.M.  2022.  Principles of Medical Virology.  In: Harrison’s Principles of Internal Medicine, 21st ed.  J. Loscalzo, et al., ed.  McGraw Hill: New York. pp. 1453-1459.
  269. Oh, H.S., F. Diaz, C. Zhou, N. Carpenter, and D.M. Knipe.  2022.  CRISPR-Cas9 Expressed in Stably Transduced Cell Lines Promotes Recombination and Selects for Herpes Simplex Virus Recominants.  Curr Rev Virol Sci 3:100023.