Knipe Lab | Harvard Medical School

Validation of human sensory neurons derived from inducible pluripotent stem cells as a model for latent infection and reactivation by herpes simplex virus 1 (Oh et al., 2025)
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Individuals who are interested in graduate study in my lab or the Harvard Virology Program are encouraged to consult the Program website for information.

Science Viewpoint: COVID Ensuring vaccine safety (abstract, PDF)

Viral Hideout—New research reveals what enables the herpesvirus to lurk in nerve cells

A bridge for promising research

HIV inhibitor may also block herpes virus infection (Harvard News)

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection (Merkl & Knipe, 2019)
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We study the molecular and cellular biology of herpes simplex virus productive and latent infection and the mechanism of the host immune response to HSV. We also have been studying a candidate genital herpes vaccine that we have developed, and we are constructing and studying HSV recombinants as vaccine vectors for AIDS, SARS, West Nile and anthrax vaccines. Please look at the material on our website describing research projects, publications, lab pictures, and contact me if you are interested in participating in this research.

With best wishes,

David M. Knipe, Ph.D.
Higgins Professor of Microbiology and Molecular Genetics

C.V.

Donate to the Knipe Lab:
Gifts can be made using the Harvard Online Giving Form for Harvard Medical School. To ensure that your gift is directed to the Knipe Lab, please choose "Other" in the "Select a Fund" drop-down menu and enter “Knipe Lab Research Fund (520-362612)” in the "Other Fund Name" field. Your gift will then be directed to the Knipe Lab Research Fund.