Department of Microbiology
Blavatnik Institute
Harvard Medical School
Home Research
People Genital Herpes
Publications Training

ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress (Cabral et al., 2018)

Individuals who are interested in graduate study in my lab or the Harvard Virology Program are encouraged to consult the Program website for information.


Viral Hideout—New research reveals what enables the herpesvirus to lurk in nerve cells 

A bridge for promising research

HIV inhibitor may also block herpes virus infection (Harvard News)

Study: New Way To Hold Back Herpes, Keep Virus Latent

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection (Merkl & Knipe, 2019)

We study the molecular and cellular biology of herpes simplex virus productive and latent infection and the mechanism of the host immune response to HSV. We also have been studying a candidate genital herpes vaccine that we have developed, and we are constructing and studying HSV recombinants as vaccine vectors for AIDS, SARS, West Nile and anthrax vaccines. Please look at the material on our website describing research projects, publications, lab pictures, and contact me if you are interested in participating in this research.

With best wishes,

David M. Knipe, Ph.D.
Higgins Professor of Microbiology and Molecular Genetics